Avoiding Medical Errors Avoiding Medical Errors

Healthy Eating Healthy Eating

Vitamins Vitamins

Angel Flights - Providing Children With Flights to Cancer Treatment in Different Cities Angel Flights

Healthy Foods Healthy Foods


Cancer Books
Bone Cancer
Brain Cancer
Breast Cancer
Childhood Leukemia
Lung Cancer
Prostate Disease
Skin Cancer

Site Map

Information About Cancer and Cancer Treatment

Breast cancer

Breast cancer is the commonest form of cancer in females. 99% of cases occur in women, but men can also develop breast cancer (see sex and illness). Breast cancer can be detected by a woman when washing, by her partner during foreplay, by formal breast self-examination or by screening mammography. Only mammography has been shown to reduce mortality from breast cancer. On finding a lump, the next step should be to visit the family doctor. The usual investigations should include an examination and mammogram. An ultrasound and biopsy may also be undertaken. If there is suspicion or confirmation of problems at this stage, the patient will be seen by a surgeon. Many large centres have 'breast' surgeons, and even in centres with 2-3 surgeons it is probably better to see the one with an interest in breast cancer. If breast cancer is confirmed by biopsy or by open excision, the diagnosis has been established. The second phase is then tumour staging which deals with questions of how big, how much and how far. The breast lump must be excised either as a local operation called lumpectomy or as a larger operation called mastectomy. In either case the surgeon must establish that the cancer has been completely excised (clear margins) by the operation. If the lumpectomy operation does not have clear margins, then the operation should be repeated until clear. The lymph nodes in the axilla also need to be studied. In the past, large axillary operations took out 10-40 nodes to establish whether cancer had spread. More recently sentinel biopsy has become popular as it has far fewer side effects. In some cases at high risk, CT scans, chest X-rays and blood tests will also be advisable to look for any metastasis or secondary cancer that has spread a long way from the site of the primary tumour. Oncologists then assign a TNM code as a shorthand categorisation which in turn determines treatment recommendations. SOme biological features of the cancer such as estrogen receptor and HER2-neu oncogene are also determined as they also affect treatment recommendations. At present, the treatment recommendations follow this pattern: 1. after a lumpectomy, the high local recurrence risk (~40%) is reduced by radiotherapy to the breast 2. if the lymph nodes are positive, the high mortality risk (30-80%) is reduced by systemic treatment (which could be either hormones or chemotherapy). 3. in young patients, the most useful systemic therapy is chemotherapy (usually regimens such as CMF, AC and/or taxol) 4. in old patients, the most useful systemic therapy is hormone therapy (tamoxifen) 5. in old patients, chemotherapy has increasing side effects as the patients passes 65 6. in patients with estrogen receptor negative tumours, the most useful systemic therapy is chemotherapy 7. in patients with estrogen receptor positive tumours, the most useful systemic therapy is hormone therapy For some early tumours, systemic treatments may not be recommended. After mastectomy, radiotherapy may not be recommended. For advanced tumours, there is an established role for all three modalities of treatment (surgery, radiation, systemic therapy) as the combination produces the best results. A gene, BRCA1, has been linked to the familial form of breast cancer. Women in families expressing this gene have a much higher risk of developing breast cancer than the average woman. Several things have been statistically linked to an increased risk of having breast cancer. The greatest risk by far is being female - females are about 100 times more likely than males to get breast cancer. Other established risk factors include having the first child late, having no children, not breastfeeding, having early menarche and late menopause, taking the contraceptive pill and taking hormone therapy.

Cancer - List of Famous Cancer Patients - Medical Topics - Medical_Terms - Medicine - Alternative Therapies -

This content from Wikipedia is licensed under the GNU Free Documentation License.
Links - HOME - Help build the worlds largest free encyclopedia.


Note: nothing on this site is intended to diagnose, treat, cure, or prevent any disease or medical condition. Always follow the advice of a licensed medical doctor.   Home | Site Map |